Description

p-Nitrobenzyl Iodide is a versatile and highly reactive organic iodide compound, serving as a critical building block in advanced chemical synthesis. Its primary value lies in its ability to act as an efficient alkylating agent and a key precursor for introducing the p-nitrobenzyl protecting group, which is essential in peptide and pharmaceutical chemistry. This compound is particularly vital for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protective groups or specific molecular fragments.
• Peptide Synthesis: Used as a reagent for the protection of carboxylic acids via the formation of p-nitrobenzyl esters, which are cleavable under mild conditions.
• Agrochemical Research: Serves as a building block in the development of novel herbicides, fungicides, and other crop protection agents.
• Material Science: Employed in the synthesis of functionalized organic molecules and ligands for catalysts or advanced materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Organic Synthesis Reagent: Acts as a versatile alkylating agent in various nucleophilic substitution reactions to form carbon-carbon and carbon-heteroatom bonds.

Basic Information

Item	Details
Product Name	p-Nitrobenzyl Iodide
CAS No.	3145-86-6
Molecular Formula	C7H6INO2
Molecular Weight	263.03 g/mol
Synonyms	1-(Iodomethyl)-4-nitrobenzene; 4-Nitrobenzyl Iodide; p-Nitrobenzyl Iodide; (4-Nitrophenyl)methyl Iodide; PNBI; α-Iodo-4-nitrotoluene; 4-Nitro-α-iodotoluene; 4-Nitrobenzyl Iodide (PNB-I)
EINECS	221-558-1

Quality Control

Our p-Nitrobenzyl Iodide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature and properties as a strong oxidizer, it must be segregated from incompatible materials such as reducing agents and combustible organics.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	97 - 101 °C
Heavy Metals (as Pb)	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.