Description

N-Phthaloyl-DL-glutamic anhydride is a high-purity, versatile chemical intermediate derived from glutamic acid and phthalic anhydride. This compound is critical for the synthesis of complex molecules, offering a protected form of glutamic acid that enables precise and efficient chemical transformations. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing active pharmaceutical ingredients (APIs), peptides, and other specialty compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic pathways.
• Peptide Synthesis: Used as a protected amino acid derivative for the controlled construction of peptides and peptidomimetics in solid-phase and solution-phase synthesis.
• Organic Synthesis: Serves as a versatile precursor for introducing glutamic acid moieties into complex organic molecules, including chiral auxiliaries and catalysts.
• Bioconjugation & Linker Chemistry: Employed in the development of chemical linkers and probes for bioconjugation applications in diagnostic and therapeutic research.
• Academic & Industrial R&D: Essential for chemical research in universities and corporate labs focused on medicinal chemistry and material science.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, including advanced polymers and liquid crystals.

Basic Information

Product Name	N-Phthaloyl-DL-glutamic anhydride
CAS No.	3085-92-5
Molecular Formula	C₁₃H₉NO₅
Molecular Weight	259.22 g/mol
Synonyms	DL-2-Phthalimido-pentanedioic Anhydride; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic Anhydride; N-Phthaloylglutamic Anhydride; Phthaloyl-DL-glutamic Anhydride; PGAn; Phthalimidoglutaric Anhydride; 2-Phthalimidoglutaric Anhydride; 2-(1,3-Dioxoisoindolin-2-yl)glutaric Anhydride
EINECS	221-393-5

Quality Control

Our N-Phthaloyl-DL-glutamic anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and loss on drying for moisture content, to ensure it meets the high standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Melting Point	158°C - 165°C
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.