Description

2-Bromo-5-Fluorobenzoic Acid is a high-purity halogenated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functionalization, providing reactive handles for cross-coupling and further derivatization to create complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the fluorine and bromine substituents for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions, such as Suzuki and Buchwald-Hartwig amination.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials due to its aromatic core and halogen atoms.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and R&D Laboratories: Used extensively in medicinal chemistry and organic synthesis research for constructing complex heterocycles and novel compounds.

Basic Information

Product Name	2-Bromo-5-Fluorobenzoic Acid
CAS No.	394-28-5
Molecular Formula	C7H4BrFO2
Molecular Weight	219.01 g/mol
Synonyms	5-Fluoro-2-bromobenzoic Acid; 2-Bromo-5-fluorobenzoic acid; Benzoic acid, 2-bromo-5-fluoro-; 5-Fluoro-o-bromobenzoic Acid; 2-Bromo-5-fluorobenzenecarboxylic Acid; NSC 403108; AI3-52066; BRN 2090497
EINECS	206-904-5

Quality Control

Our 2-Bromo-5-Fluorobenzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment ensures reliability for your most demanding GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.