Description

Trifluoromethylphosphonic Acid is a specialized organophosphorus compound featuring a highly electronegative trifluoromethyl group directly bonded to a phosphonic acid moiety. This unique structure imparts strong acidity and makes it a valuable building block and key intermediate in advanced chemical synthesis. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, as well as in materials science for creating specialized ligands and surface modifiers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition where the phosphonic acid group acts as a bioisostere for phosphate.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, pesticides, and plant growth regulators, leveraging its stability and reactivity.
• Ligand and Catalyst Design: Serves as a starting material for creating specialized phosphonate-based ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Surface Modification Agent: Employed to functionalize material surfaces (e.g., metals, oxides) to alter wettability, corrosion resistance, or adhesion properties.
• Flame Retardant Additive: Investigated as a potential component in flame-retardant formulations due to the presence of both phosphorus and fluorine.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new reactions in organofluorine and organophosphorus chemistry.

Basic Information

Product Name	Trifluoromethylphosphonic Acid
CAS No.	374-09-4
Molecular Formula	CH2F3O3P
Molecular Weight	149.99 g/mol
Synonyms	(Trifluoromethyl)phosphonic Acid; Phosphonic Acid, P-(Trifluoromethyl)-; α,α,α-Trifluoromethylphosphonic Acid; TFMPA; Trifluoromethanephosphonic Acid; 1,1,1-Trifluoromethanephosphonic Acid; (Trifluoromethyl)Phosphonic Acid; P-Trifluoromethylphosphonic Acid
EINECS	206-785-5

Quality Control

Our Trifluoromethylphosphonic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹⁹F, ³¹P), HPLC, and titration methods, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, containers should be kept tightly sealed and constructed of compatible materials (e.g., PTFE-lined). Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (by Titration)	≥ 97.0%
Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.