Description

2-{[3-(Trifluoromethyl)Phenyl]Amino}Acetic Acid is a specialized trifluoromethylated aniline derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. This compound is prized for its ability to introduce both an amino acid moiety and a highly lipophilic, electron-withdrawing trifluoromethyl group into target molecules, significantly altering their physicochemical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in the development of enzyme inhibitors, receptor modulators, and bioactive molecules where the CF₃ group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and material science applications.
• Advanced Material Research: Employed in the development of organic semiconductors, liquid crystals, and polymers where specific electronic properties are required.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-{[3-(Trifluoromethyl)Phenyl]Amino}Acetic Acid
CAS No.	349-81-5
Molecular Formula	C₉H₈F₃NO₂
Molecular Weight	219.16 g/mol
Synonyms	N-[3-(Trifluoromethyl)phenyl]glycine; (3-Trifluoromethylphenylamino)acetic Acid; 2-[(3-Trifluoromethylphenyl)amino]acetic Acid; m-Trifluoromethylphenylglycine; α-Amino[3-(trifluoromethyl)phenyl]acetic Acid; Glycine, N-[3-(trifluoromethyl)phenyl]-; 349-81-5; NSC 163049
EINECS	Contact for details

Quality Control

Our production of 2-{[3-(Trifluoromethyl)Phenyl]Amino}Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.