Description

2-Amino-4'-Chloro-4-Trifluoromethyl Diphenyl Ether is a high-purity, halogenated aromatic amine building block of significant commercial importance. Its unique trifluoromethyl and chloro-substituted biphenyl ether structure makes it a versatile intermediate for synthesizing advanced materials and active pharmaceutical ingredients. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for creating novel liquid crystal molecules and organic light-emitting diode (OLED) materials, leveraging its rigid, halogenated aromatic structure.
• Polymer & Resin Modifier: Incorporated into high-performance polymers and epoxy resins to impart specific characteristics like thermal stability, chemical resistance, or altered refractive index.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments, where its amino and halogen groups allow for precise color tuning and fastness properties.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex biaryl structures in medicinal chemistry.

Basic Information

Product Name	2-Amino-4'-Chloro-4-Trifluoromethyl Diphenyl Ether
CAS No.	349-20-2
Molecular Formula	C13H9ClF3NO
Molecular Weight	287.66 g/mol
Synonyms	4-Chloro-2'-(trifluoromethyl)diphenylamine; 2-Amino-4'-chloro-α,α,α-trifluoro-p-tolyl ether; 1-Chloro-4-[(2-amino-5-(trifluoromethyl)phenoxy]benzene; 4'-Chloro-2-amino-4-trifluoromethyl diphenyl ether; Benzenamine, 4-chloro-2'-(trifluoromethyl)-; 2-Amino-4-chloro-α,α,α-trifluoro-p-tolyl ether; 4-Chloro-2'-(trifluoromethyl)benzenamine
EINECS	Contact for details

Quality Control

Our 2-Amino-4'-Chloro-4-Trifluoromethyl Diphenyl Ether is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture, which may affect stability and performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.