Description

2-Nitro-4-Trifluoromethylbenzoic Acid is a high-value fluorinated aromatic building block characterized by its nitro and trifluoromethyl substituents. This compound is essential for synthesizing advanced agrochemicals and pharmaceuticals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core for enhanced potency and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in organic synthesis to construct complex chelating ligands or organocatalysts for asymmetric transformations.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized fluorinated dyes and pigments with unique color fastness and chemical resistance.

Basic Information

Product Name	2-Nitro-4-Trifluoromethylbenzoic Acid
CAS No.	320-94-5
Molecular Formula	C8H4F3NO4
Molecular Weight	235.12 g/mol
Synonyms	2-Nitro-α,α,α-trifluoro-p-toluic Acid; 4-(Trifluoromethyl)-2-nitrobenzoic Acid; Benzoic acid, 2-nitro-4-(trifluoromethyl)-; 2-Nitro-4-trifluoromethylbenzoic acid; α,α,α-Triflu-oro-2-nitro-4-toluic Acid; 2-Nitro-4-trifluoromethyl-benzoic acid; 2-Nitro-4-(trifluoromethyl)benzoic acid
EINECS	206-280-6

Quality Control

Every batch of 2-Nitro-4-Trifluoromethylbenzoic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and IR spectroscopy to verify identity and purity. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.