Description

4-Bromo-2-Fluoro-6-Nitrophenol is a halogenated nitrophenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), advanced materials, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the bromo and fluoro substituents contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro group and halogen atoms.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex azo dyes and high-performance pigments.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for biochemical research and diagnostic applications.

Basic Information

Product Name	4-Bromo-2-Fluoro-6-Nitrophenol
CAS No.	320-76-3
Molecular Formula	C6H3BrFNO3
Molecular Weight	235.99 g/mol
Synonyms	2-Fluoro-4-bromo-6-nitrophenol; 6-Nitro-4-bromo-2-fluorophenol; Phenol, 4-bromo-2-fluoro-6-nitro-; 4-Bromo-2-fluoro-6-nitro-1-hydroxybenzene; 2-Fluoro-6-nitro-4-bromophenol; 4-Bromo-2-fluoro-6-nitrophenol (BFNP)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-6-Nitrophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.