Description

1-Bromo-5-Fluoronaphthalene is a halogenated naphthalene derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as Suzuki cross-coupling reactions and the development of liquid crystals or organic semiconductors.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and pesticides, where the introduction of fluorine can enhance biological activity and metabolic stability.
• Organic Electronic Materials: Serves as a precursor for constructing π-conjugated systems in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Liquid Crystal Synthesis: An important intermediate for creating fluorinated liquid crystal compounds used in display technologies.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a model substrate for developing new halogenation, functionalization, and coupling methodologies.
• Fluorine Chemistry Studies: Acts as a standard or starting material for investigating the effects of fluorine substitution on aromatic systems and reaction pathways.

Basic Information

Product Name	1-Bromo-5-Fluoronaphthalene
CAS No.	315-56-0
Molecular Formula	C₁₀H₆BrF
Molecular Weight	225.06 g/mol
Synonyms	5-Fluoro-1-bromonaphthalene; 1-Bromo-5-fluoronaphthalene; 5-Fluoronaphthalen-1-yl bromide; Naphthalene, 1-bromo-5-fluoro-; 1-Brom-5-fluornaphthalin; 1-Bromo-5-fluoronaftaleno; 1-ブロモ-5-フルオロナフタレン
EINECS	206-257-5

Quality Control

Our 1-Bromo-5-Fluoronaphthalene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.