Description

1H-Isoindole, 1,3-Bis[[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Methylene]-2,3-Dihydro-, (1Z,3Z)- is a sophisticated chiral organic compound featuring a unique isoindole core symmetrically functionalized with two (4R)-configured oxazoline units. This compound matters as a high-value specialty chemical intermediate and ligand precursor, prized for its potential to impart stereoselectivity in complex synthetic transformations. It is primarily needed by research institutions and industrial R&D departments engaged in advanced pharmaceutical development, asymmetric catalysis, and the synthesis of novel functional materials.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral ligands used in enantioselective synthesis, including hydrogenation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediates: A key building block in the research and development of active pharmaceutical ingredients (APIs) requiring complex, stereodefined molecular architectures.
• Material Science Research: Investigated for the development of chiral organic frameworks, polymers, or liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms or biological recognition events due to its rigid, multifunctional structure.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis within university and corporate research laboratories.

Basic Information

Product Name	1H-Isoindole, 1,3-Bis[[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Methylene]-2,3-Dihydro-, (1Z,3Z)-
CAS No.	2828432-08-0
Molecular Formula	C30H28N2O2
Molecular Weight	448.56 g/mol
Synonyms	(1Z,3Z)-1,3-Bis[[(4R)-4,5-Dihydro-4-Benzyl-2-Oxazolyl]Methylene]-2,3-Dihydro-1H-Isoindole; (Z,Z)-1,3-Bis[(4R)-4-Benzyl-4,5-dihydrooxazol-2-yl)methylene]isoindoline; Chiral Bis(oxazoline) Isoindole Derivative; (1Z,3Z)-1,3-Bis{[(4R)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]methylene}-2,3-dihydro-1H-isoindole; BOX-Isoindole Ligand Precursor
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for purity, enantiomeric excess, and impurity profiles are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.