Description

Dbco-Peg8-Acid CAS NO 2765066-35-9 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry and a carboxylic acid terminus for further conjugation. This compound is essential for creating stable, bioconjugate structures without the need for cytotoxic copper catalysts, enabling the development of advanced biotherapeutics and diagnostics. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the synthesis of PEGylated nanoparticles and biomaterials.

Application

• Bioconjugation and ADC Development: Used as a key linker for site-specific conjugation of cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides via its DBCO and carboxylic acid functional groups.
• PEGylation Reagent: Serves to introduce a hydrophilic PEG spacer to biomolecules, nanoparticles, or surfaces, improving solubility, stability, and pharmacokinetic profiles.
• Click Chemistry Reagent: Enables efficient, bioorthogonal SPAAC reactions with azide-modified molecules for labeling, crosslinking, and surface functionalization in biological systems.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging probes and biosensors by linking targeting moieties to reporter molecules.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinker or functional component in the creation of advanced polymeric materials for drug delivery and tissue engineering.
• Oligonucleotide Modification: Used to introduce PEG chains onto nucleic acids (DNA, RNA) to enhance nuclease resistance and cellular uptake.

Basic Information

Product Name	Dbco-Peg8-Acid
CAS No.	2765066-35-9
Molecular Formula	C45H73NO16
Molecular Weight	884.06 g/mol
Synonyms	DBCO-PEG8-COOH; DBCO-PEG8-Acid; Dibenzocyclooctyne-PEG8-Acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-((2-(2-(2-(2-(2-(2-(2-(2-carboxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate); DBCO-PEG8-Acetic Acid; DBCO-PEG8-Propionic Acid (common misnomer); Azadibenzocyclooctyne-PEG8-Acid; DBCO-PEG8-CH2COOH
EINECS	Contact for details

Quality Control

Our Dbco-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.