Description

(1S)-2,2,2-Trifluoro-1-Methylethyl]Hydrazine Hydrochloride is a high-purity, chiral fluorinated hydrazine derivative supplied as a hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the introduction of a trifluoromethyl-bearing stereocenter. It is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability. The product is offered with guaranteed purity and batch-to-batch consistency to support demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Asymmetric Synthesis: Used in the preparation of chiral ligands, auxiliaries, and catalysts for stereoselective transformations.
• Fluorine Chemistry Research: Valuable reagent for studying the effects of the trifluoromethyl group on molecular properties and biological activity.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation.
• Material Science Precursor: Potential intermediate in the synthesis of specialty polymers and advanced materials.

Basic Information

Product Name	(1S)-2,2,2-Trifluoro-1-Methylethyl]Hydrazine Hydrochloride
CAS No.	2764851-03-6
Molecular Formula	C3H8ClF3N2
Molecular Weight	164.55 g/mol
Synonyms	(S)-1,1,1-Trifluoropropan-2-yl]hydrazine hydrochloride; (1S)-1,1,1-Trifluoro-2-propylhydrazine hydrochloride; (S)-2,2,2-Trifluoro-1-methylethylhydrazine HCl; (S)-α-(Trifluoromethyl)ethylhydrazine hydrochloride; (S)-1-Amino-2,2,2-trifluoropropane hydrochloride; (S)-TFMPH hydrochloride; Chiral Trifluoromethyl Hydrazine Hydrochloride
EINECS	Contact for details

Quality Control

Our (1S)-2,2,2-Trifluoro-1-Methylethyl]Hydrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic chemistry. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.