Description

(1S)-2,2,2-Tri-Fluoro-1-Methyl-Ethyl]Hydrazine is a high-purity, chiral fluorinated hydrazine derivative of significant interest in advanced chemical synthesis. This compound matters as a specialized building block for introducing the trifluoroethylhydrazine moiety with defined stereochemistry, enabling the development of novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the fluorinated group can improve lipophilicity and target binding.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Compound Library Synthesis: Essential for constructing diverse screening libraries in drug discovery, leveraging the unique properties of fluorine.
• Material Science Precursor: Potential use in synthesizing fluorinated polymers or specialty materials with specific surface properties.

Basic Information

Product Name	(1S)-2,2,2-Tri-Fluoro-1-Methyl-Ethyl]Hydrazine
CAS No.	2764851-02-5
Molecular Formula	C3H7F3N2
Molecular Weight	128.10 g/mol
Synonyms	(S)-1,1,1-Trifluoro-2-propylhydrazine; (1S)-1,1,1-Trifluoro-2-propylhydrazine; (S)-2,2,2-Trifluoro-1-methylethylhydrazine; (S)-Trifluoroethylmethylhydrazine; (S)-α-Trifluoromethyl ethylhydrazine; (S)-TFMEH; (S)-1-Amino-2,2,2-trifluoropropane
EINECS	Contact for details

Quality Control

Our (1S)-2,2,2-Tri-Fluoro-1-Methyl-Ethyl]Hydrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.