Description

n-[(11Bs)-2,6-Bis(3,5-Dimethylphenyl-4-Oxidodinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]-1,1,1-Trifluoro-Methanesulfonamide is a sophisticated organophosphorus compound, specifically a chiral phosphine-oxazoline (PHOX) ligand derivative, designed for high-performance asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates. This advanced ligand is essential for R&D and production chemists in the pharmaceutical and fine chemical industries, where it is used to create chiral active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions such as Heck couplings, Suzuki-Miyaura cross-couplings, and allylic alkylations with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of single-enantiomer building blocks for complex drug molecules.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science Research: Facilitates the synthesis of chiral polymers and advanced organic materials with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic transformations in academic and corporate research laboratories.

Basic Information

Product Name	n-[(11Bs)-2,6-Bis(3,5-Dimethylphenyl-4-Oxidodinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]-1,1,1-Trifluoro-Methanesulfonamide
CAS No.	2757287-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(S)-2,6-Bis(3,5-dimethylphenyl)-4-(1,1,1-trifluoro-N-sulfonylamido)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; Chiral PHOX Ligand Derivative; Trifluoromethanesulfonamide-substituted PHOX Ligand; Asymmetric Phosphine-Oxazoline Ligand; (S)-DTBM-PHOX-TfNH; BINAPHOX Analogue; Organophosphorus Catalyst Ligand; CAS 2757287-64-0
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced under strict quality management to ensure consistency and performance in sensitive catalytic applications. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify chemical purity, structural identity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chiral purity is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.