Description

Pyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-6-Phenyl- is a high-purity, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated building block and ligand in advanced chemical synthesis. Its value lies in its ability to impart stereoselectivity and modulate reactivity in catalytic processes, making it critical for the production of complex, high-value molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise molecular control.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders or possessing complex stereocenters.
• Asymmetric Catalysis Ligand: Used as a nitrogen-oxygen (N,O) bidentate ligand for transition metal catalysts (e.g., copper, palladium, zinc) to enable enantioselective transformations like cyclopropanations or conjugate additions.
• Agrochemical Synthesis: Employed in the research and development of novel, stereochemically defined herbicides, fungicides, and plant growth regulators.
• Material Science Research: Acts as a functional monomer or coordinating agent in the development of chiral polymers, metal-organic frameworks (MOFs), or advanced optical materials.
• Academic & Process R&D: A valuable tool for methodology development in organic chemistry, enabling the exploration of new catalytic cycles and reaction pathways.

Basic Information

Product Name	Pyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-6-Phenyl-
CAS No.	2757082-75-8
Molecular Formula	C18H20N2O
Molecular Weight	280.37 g/mol
Synonyms	(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)-6-phenylpyridine; (4R)-4-(tert-Butyl)-2-(6-phenyl-2-pyridinyl)-4,5-dihydro-1,3-oxazole; 2-[(4R)-4-(tert-Butyl)-4,5-dihydro-1,3-oxazol-2-yl]-6-phenylpyridine; (R)-4-(tert-Butyl)-2-(6-phenylpyridin-2-yl)-4,5-dihydrooxazole; Chiral Pyridine-Oxazoline Ligand; (R)-PyOx Ligand Derivative; tert-Butyl PyOx-Ph; 2-(6-Phenylpyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole (R-enantiomer)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.