Description

1,8-Naphthyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]- is a sophisticated chiral heterocyclic compound that serves as a high-value synthetic intermediate and building block. Its unique fused-ring structure, incorporating both naphthyridine and oxazoline moieties, makes it a critical scaffold for advanced research and development in medicinal chemistry. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides and pesticides with targeted activity.
• Material Science: Investigated as a monomer or functional unit for creating advanced polymers and organic electronic materials.
• Academic & Industrial R&D: Essential for methodological studies in organic synthesis and for exploring new chemical spaces in discovery chemistry.

Basic Information

Product Name	1,8-Naphthyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-
CAS No.	2757082-67-8
Molecular Formula	C14H15N3O
Molecular Weight	241.29 g/mol
Synonyms	(4R)-2-(1,8-Naphthyridin-2-yl)-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole; (R)-2-(1,8-Naphthyridin-2-yl)-4-isopropyl-4,5-dihydrooxazole; 2-[(4R)-4,5-Dihydro-4-(1-methylethyl)-2-oxazolyl]-1,8-naphthyridine; Chiral 1,8-Naphthyridine-oxazoline ligand precursor; (R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-2-oxazoline
EINECS	Contact for details

Quality Control

Every batch of 1,8-Naphthyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]- is manufactured and tested under strict quality management systems to ensure high purity, chiral integrity, and batch-to-batch consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider using an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.