Description

1,8-Naphthyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]- is a high-purity, chiral organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound, with CAS number 2757082-56-5, is valued for its rigid, fused bicyclic structure and the presence of a stereogenic center, making it a critical building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for antiviral, anticancer, and anti-inflammatory therapies.
• Ligand Synthesis: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Serves as a core structure for developing new pesticides and herbicides with enhanced specificity and activity.
• Material Science: Investigated as a precursor for organic electronic materials and fluorescent probes due to the naphthyridine core's photophysical properties.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	1,8-Naphthyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-
CAS No.	2757082-56-5
Molecular Formula	C15H17N3O
Molecular Weight	255.32 g/mol
Synonyms	(4R)-2-(1,8-Naphthyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; (R)-2-(1,8-Naphthyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; 2-[(4R)-4-(tert-Butyl)-4,5-dihydro-1,3-oxazol-2-yl]-1,8-naphthyridine; 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-1,8-naphthyridine; Chiral Naphthyridine-Oxazoline Ligand Precursor; (R)-t-Bu-NaphthyOx
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity, with specifications typically meeting or exceeding 98% purity (HPLC). A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess (ee), and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.