Description

3-(Bromomethyl)Bicyclo[1.1.1]pentane-1-carboxylic acid is a high-value, functionalized bicyclic building block of significant interest in modern organic synthesis and medicinal chemistry. This compound is prized for its rigid, three-dimensional [1.1.1]propellane core, which serves as a bioisostere for linear alkynes or para-substituted benzene rings, enabling the creation of novel molecular architectures with improved physicochemical properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, chemical biology, and ligand design.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Bioisostere Incorporation: Used to replace linear linkers or aromatic rings in lead optimization to enhance metabolic stability, solubility, and binding affinity.
• Chemical Biology Probes: Serves as a versatile handle for constructing activity-based probes or PROTACs (Proteolysis Targeting Chimeras) due to its reactive bromomethyl group.
• Agrochemical Research: Employed in the development of new herbicides and fungicides with novel modes of action.
• Materials Science: Acts as a monomer or cross-linking agent for creating polymers with unique mechanical and thermal properties.
• Peptidomimetics: Facilitates the synthesis of constrained peptide analogs to improve bioavailability and selectivity.
• Ligand Synthesis for Catalysis: Used to prepare novel, sterically demanding ligands for transition metal catalysis.

Basic Information

Product Name	3-(Bromomethyl)Bicyclo[1.1.1]pentane-1-carboxylic Acid
CAS No.	2742661-04-5
Molecular Formula	C8H9BrO2
Molecular Weight	217.06 g/mol
Synonyms	3-(Bromomethyl)[1.1.1]propellane-1-carboxylic acid; 1-Carboxy-3-(bromomethyl)bicyclo[1.1.1]pentane; [1.1.1]Propellane-1-carboxylic acid, 3-(bromomethyl)-; BCP-Br-COOH; 3-Bromomethyl-BCP-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)Bicyclo[1.1.1]pentane-1-carboxylic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.