Description

5-(Trifluoromethyl)Quinoline-6-Carboxylic Acid CAS NO 2703752-33-2 is a high-value, multi-functional heterocyclic building block characterized by its quinoline core and trifluoromethyl substituent. This compound is essential for medicinal chemistry and advanced materials research, where its unique structure enables the fine-tuning of molecular properties such as lipophilicity, metabolic stability, and electronic characteristics. It is primarily sought after by pharmaceutical R&D teams and agrochemical innovators for the synthesis of novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Used to construct advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient quinoline structure.
• Fluorinated Compound Library Building: A critical component for combinatorial chemistry and high-throughput screening to discover new fluorinated bioactive molecules.

Basic Information

Product Name	5-(Trifluoromethyl)Quinoline-6-Carboxylic Acid
CAS No.	2703752-33-2
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	6-Quinolinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-6-quinolinecarboxylic acid; 5-Trifluoromethylquinoline-6-carboxylic acid; Quinoline-6-carboxylic acid, 5-(trifluoromethyl)-; 2703752-33-2; 5-CF3-Quinoline-6-COOH
EINECS	Contact for details

Quality Control

We maintain a strict quality management system aligned with cGMP principles for advanced intermediates. Every batch of 5-(Trifluoromethyl)Quinoline-6-Carboxylic Acid is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.