Description

L-Phenylalanine, Chloro-, Hydrochloride (1:2) is a chemically modified derivative of the essential amino acid L-phenylalanine, characterized by the introduction of a chloro substituent and isolated as a dihydrochloride salt. This specialized building block is of significant value in pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of peptide drugs and other bioactive molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates with modified properties.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex organic molecules in fine chemical manufacturing.

Basic Information

Product Name	L-Phenylalanine, Chloro-, Hydrochloride (1:2)
CAS No.	2701679-69-6
Molecular Formula	C9H11ClNO2 • 2HCl
Molecular Weight	286.01 g/mol (Free base: 215.65)
Synonyms	(2S)-2-Amino-3-(4-chlorophenyl)propanoic acid dihydrochloride; 4-Chloro-L-phenylalanine dihydrochloride; p-Chloro-L-phenylalanine dihydrochloride; PCPA dihydrochloride; L-4-Chlorophenylalanine dihydrochloride; (S)-2-Amino-3-(4-chlorophenyl)propionic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, Chloro-, Hydrochloride (1:2) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and related substances is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.