Description

Pyridine, 2-[(4S,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-(Diphenylmethyl)- is a highly specialized chiral oxazoline-substituted pyridine derivative, serving as a critical building block and ligand in advanced organic synthesis. Its precise stereochemistry and complex molecular architecture make it invaluable for facilitating asymmetric catalytic reactions, enabling the production of enantiomerically pure compounds. This high-purity intermediate is essential for research and development in the pharmaceutical and fine chemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and high-value specialty chemicals.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal catalysts in enantioselective synthesis, including hydrogenation, cyclopropanation, and cross-coupling reactions.
• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex, stereochemically defined drug candidates and active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Used in the production of high-value specialty chemicals, agrochemicals, and performance materials where precise chirality is required.
• Academic & Industrial R&D: A valuable tool for chemists in research laboratories developing new synthetic methodologies and exploring novel chemical space.
• Ligand for Metal Complexation: Forms stable complexes with various metals, useful in catalysis and material science applications.

Basic Information

Product Name	Pyridine, 2-[(4S,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-(Diphenylmethyl)-
CAS No.	2645354-83-0
Molecular Formula	C33H26N2O
Molecular Weight	466.57 g/mol
Synonyms	6-(Diphenylmethyl)-2-[(4S,5R)-4,5-dihydro-4,5-diphenyl-2-oxazolyl]pyridine; (4S,5R)-2-[6-(Diphenylmethyl)pyridin-2-yl]-4,5-diphenyl-4,5-dihydrooxazole; Chiral Pyridine-Oxazoline Ligand; (S,R)-PyOx Ligand Derivative; Asymmetric Catalyst Ligand; Diphenylmethyl-Substituted PyOx; 2-(4,5-Dihydro-4,5-diphenyloxazol-2-yl)-6-(diphenylmethyl)pyridine
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to stringent quality protocols. Every batch is characterized and purified to meet exacting research and pharmaceutical-grade standards, with purity typically exceeding 97% (by HPLC). Identity and stereochemical purity are confirmed via NMR, HPLC, and optical rotation analysis. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profiles is provided with each shipment to ensure traceability and compliance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.