Description

(3S)-3-(2,2,2-Trifluoroethyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its trifluoroethyl-substituted pyrrolidine scaffold, which is crucial for modulating the physicochemical and metabolic properties of active pharmaceutical ingredients. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms for improved metabolic stability and membrane permeability.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of potential APIs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands for catalysis or metal complexation.
• Life Science Reagent: Used in biochemical research as a tool compound for probing biological pathways.

Basic Information

Product Name	(3S)-3-(2,2,2-Trifluoroethyl)Pyrrolidine Hydrochloride
CAS No.	2639960-45-3
Molecular Formula	C6H11ClF3N
Molecular Weight	189.61 g/mol
Synonyms	(S)-3-(2,2,2-Trifluoroethyl)pyrrolidine hydrochloride; (3S)-3-(2,2,2-Trifluoroethyl)-1-azacyclopentane hydrochloride; (S)-3-(Trifluoroethyl)pyrrolidine HCl; Pyrrolidine, 3-(2,2,2-trifluoroethyl)-, hydrochloride, (3S)-; 2639960-45-3
EINECS	Contact for details

Quality Control

Our (3S)-3-(2,2,2-Trifluoroethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere if the container is opened for partial use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.