Description

(S)-4-(tert-Butyl)-2-(1,8-Naphthyridin-2-Yl)-4,5-Dihydrooxazole is a high-value, chiral oxazoline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a 1,8-naphthyridine moiety and a stereogenic center, makes it an essential ligand and precursor for the development of novel pharmaceuticals and fine chemicals. This compound is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric catalysis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and oncological pathways.
• Asymmetric Catalysis Ligand: Used as a sophisticated ligand for transition metal catalysts (e.g., palladium, copper, iridium) to induce high enantioselectivity in C-C and C-N bond-forming reactions.
• Medicinal Chemistry Research: Employed in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Agrochemical Synthesis: Serves as a building block for creating novel, chiral active ingredients for crop protection products with improved efficacy and environmental profiles.
• Material Science: Investigated as a monomer or functional additive for creating advanced polymers with specific optical or electronic properties.

Basic Information

Product Name	(S)-4-(tert-Butyl)-2-(1,8-Naphthyridin-2-Yl)-4,5-Dihydrooxazole
CAS No.	2634687-69-5
Molecular Formula	C₁₇H₁₉N₃O
Molecular Weight	281.35 g/mol
Synonyms	(S)-4-(tert-Butyl)-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole; (S)-2-(1,8-Naphthyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; (S)-4-tert-Butyl-2-(1,8-naphthyridin-2-yl)-2-oxazoline; (S)-t-Bu-Naphy-Ox; Chiral Naphthyridine-Oxazoline Ligand; (S)-4,5-Dihydro-4-(1,1-dimethylethyl)-2-(1,8-naphthyridin-2-yl)oxazole
EINECS	Contact for details

Quality Control

Every batch of (S)-4-(tert-Butyl)-2-(1,8-Naphthyridin-2-Yl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity, consistent with the standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.