Description

Tri(Amino-Peg4-Amide)-Amine is a multi-arm, heterobifunctional polyethylene glycol (PEG) derivative featuring a central amine core and three amino-terminated PEG4-amide arms. This branched, multi-functional linker is engineered to facilitate the conjugation of multiple molecules or surfaces, enhancing solubility and biocompatibility in complex formulations. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise, multi-point attachment and PEGylation are required.

Application

• Bioconjugation & Cross-linking Agent: Used for creating multi-valent antibody-drug conjugates (ADCs), peptide-PEG conjugates, and protein modifications.
• Pharmaceutical PEGylation: Serves as a multi-arm PEG spacer to improve the pharmacokinetic profiles, solubility, and stability of therapeutic proteins and peptides.
• Hydrogel & Biomaterial Synthesis: Acts as a multi-functional cross-linker for creating biocompatible hydrogels for drug delivery and tissue engineering scaffolds.
• Diagnostic Reagent Formulation: Utilized in the development of contrast agents and diagnostic probes requiring multiple attachment sites for targeting ligands.
• Surface Functionalization: Enables the multi-point modification of nanoparticles, quantum dots, and sensor surfaces to enhance functionality and reduce non-specific binding.
• Dendrimer & Polymer Chemistry: Functions as a versatile building block for synthesizing complex dendritic structures and functional polymers.

Basic Information

Product Name	Tri(Amino-Peg4-Amide)-Amine
CAS No.	2523025-41-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tris(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amine; 1-Aza-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-40-azanonaheptacontane-1,40,40-triyltripropanoic acid; PEG4 Triskelion Amine; Triamino-PEG4-tris-amide; Multi-arm PEG Amine; Heterotrifunctional PEG Crosslinker; Amino-PEG4-Amide Trimer
EINECS	Contact for details

Quality Control

Our Tri(Amino-Peg4-Amide)-Amine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and oxidatively sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.