Description

Rel-(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropan-1-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecules with high enantiomeric purity for medicinal chemistry programs.
• Chemical Research: Serves as a standard or reagent in method development and structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for cost-effective API manufacturing.
• Reference Standard: Utilized as a certified reference material (CRM) for analytical method validation and quality control in GMP environments.

Basic Information

Product Name	Rel-(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropan-1-Amine Hydrochloride
CAS No.	2517869-16-6
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	(1R,2R)-2-(3,4-Difluorophenyl)cyclopropan-1-amine hydrochloride; trans-2-(3,4-Difluorophenyl)cyclopropylamine hydrochloride; 2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (rel-(1R,2R)-); 3,4-Difluorophenylcyclopropylamine HCl; 2517869-16-6; (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanamine HCl; Rel-(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
EINECS	Contact for details

Quality Control

Our Rel-(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (diastereomeric excess)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.