Description

Mal-Peg4-Amine Tfa Salt is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a primary amine, separated by a tetraethylene glycol spacer, and presented as its trifluoroacetate salt. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the creation of stable thioether bonds with cysteine residues. It is essential for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and peptide/protein modification, where precise linker chemistry and aqueous solubility are paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• PEGylation of Peptides and Proteins: Site-specific attachment of PEG chains to enhance pharmacokinetic properties like solubility and half-life.
• Biomolecule Immobilization: Functionalization of surfaces, beads, or chips with proteins or peptides for biosensor and diagnostic assay development.
• Fluorescent Probe and Label Conjugation: Preparation of labeled biomolecules for imaging, flow cytometry, and in vitro diagnostics.
• Polymer-Protein Hybrid Material Fabrication: Synthesis of advanced biomaterials for drug delivery and tissue engineering applications.
• Small Molecule-Protein Conjugation: Creating hapten-carrier protein conjugates for antibody production and vaccine development.

Basic Information

Product Name	Mal-Peg4-Amine Tfa Salt
CAS No.	2512227-13-1
Molecular Formula	C21H33F3N2O9
Molecular Weight	514.5 g/mol
Synonyms	Maleimide-PEG4-Amine TFA Salt; 4,7,10,13-Tetraoxa-16-azaheptadecan-17-oic acid, 16-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,2,2-trifluoroacetate (1:1); 1-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]methyl]-1H-pyrrole-2,5-dione trifluoroacetate; Mal-PEG4-NH2.TFA; Amine-PEG4-Maleimide TFA Salt; TFA Salt of Maleimide-PEG4-Amine; N-(Maleimidomethyl)-3,6,9,12-tetraoxapentadecan-15-amine trifluoroacetate
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Amine Tfa Salt is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.