Description

Phenylhydrogen((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel nucleoside analogs and prodrugs. This compound is critical for research and development in antiviral and anticancer therapeutic areas, offering a key building block for modifying drug delivery and efficacy. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleotide prodrugs.
• Protease Inhibitor Research: Used in the development of targeted protease inhibitors for various disease pathways.
• Antiviral Drug Development: Serves as a critical building block for compounds targeting viral polymerases and replication mechanisms.
• Bioconjugation & Prodrug Synthesis: Enables the creation of targeted drug delivery systems through phosphonate linkage chemistry.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in nucleoside analog design.
• Biochemical Assay Development: Can be used to develop enzyme substrates or inhibitors for high-throughput screening.

Basic Information

Product Name	Phenylhydrogen((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate
CAS No.	2488598-61-2
Molecular Formula	C15H18N5O4P
Molecular Weight	363.31 g/mol
Synonyms	((((S)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphonic acid phenyl ester; Phenyl ((((S)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate; Adenine isopropyloxy methylphosphonate phenyl ester (S-isomer); (S)-Phenyl (((1-(6-aminopurin-9-yl)propan-2-yl)oxy)methyl)phosphonate; 9-[(1S)-1-[[(Phenyloxyphosphinyl)methoxy]methyl]ethyl]adenine; GS-441524 phosphonate prodrug intermediate; Remdesivir-related phosphonate intermediate
EINECS	Contact for details

Quality Control

Our Phenylhydrogen((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate is manufactured under strict quality systems suitable for pharmaceutical R&D applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure consistent quality and structural integrity. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.