Description

trans-2-Amino-5,5-Difluoro-Cyclohexanol Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated cyclohexanol scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules where fluorine substitution is used to modulate potency, metabolic stability, and membrane permeability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex target structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the difluoro-cyclohexanol motif on biological activity.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the research and development of new generation pesticides and herbicides, leveraging the physicochemical properties imparted by fluorine atoms.
• Chemical Biology Probes: Useful for creating labeled or tagged compounds to study biological pathways and enzyme interactions.
• Academic Research: A valuable reagent for universities and research institutes investigating new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	trans-2-Amino-5,5-Difluoro-Cyclohexanol Hydrochloride
CAS No.	2438777-94-5
Molecular Formula	C6H10F2NO • HCl
Molecular Weight	185.60 (Free base) / 222.06 (HCl salt)
Synonyms	trans-2-Amino-5,5-difluorocyclohexanol hydrochloride; (1R,2R)-2-Amino-5,5-difluorocyclohexan-1-ol hydrochloride; (1S,2S)-2-Amino-5,5-difluorocyclohexan-1-ol hydrochloride; 5,5-Difluoro-2-aminocyclohexanol HCl; 2-Amino-5,5-difluorocyclohexanol hydrochloride; Amino-difluoro-cyclohexanol HCl; 2438777-94-5; 2-Amino-5,5-difluoro-1-cyclohexanol hydrochloride
EINECS	Contact for details

Quality Control

Our trans-2-Amino-5,5-Difluoro-Cyclohexanol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC, NMR, and MS to confirm identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (Titration)	98.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.