Description

(1S)-1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, a key building block in modern organic synthesis. Its value lies in its defined stereochemistry and the unique reactivity imparted by the fluorine and trifluoromethyl substituents, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutics.
• Agrochemical Synthesis: Serves as a building block for advanced crop protection agents, where the fluorine-containing moiety enhances stability and bioavailability.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology & Proteomics: Employed as a specialty reagent for labeling and probing biological systems.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties.

Basic Information

Item	Details
Product Name	(1S)-1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine Hydrochloride
CAS No.	2416218-85-2
Molecular Formula	C9H8F4NCl
Molecular Weight	241.62 g/mol
Synonyms	(S)-1-(2-Fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine hydrochloride; (1S)-1-[2-Fluoro-3-(trifluoromethyl)phenyl]ethylamine hydrochloride; (S)-α-Methyl-2-fluoro-3-(trifluoromethyl)benzylamine hydrochloride; (S)-1-(2-Fluoro-3-trifluoromethylphenyl)ethylamine HCl; CAS 2416218-85-2; (S)-Enantiomer of 1-(2-Fluoro-3-(trifluoromethyl)phenyl)ethanamine HCl
EINECS	Contact for details

Quality Control

Every batch of (1S)-1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine Hydrochloride is manufactured under a strict quality management system. We ensure compliance with relevant industry standards for advanced pharmaceutical intermediates. Comprehensive analytical testing, including chiral purity verification by HPLC, is performed. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.