Description

Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1), cis- is a high-value, fluorinated organic building block with a defined stereochemistry. This compound is specifically engineered to serve as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where the cis-configuration and trifluoromethyl group are essential for biological activity. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique surface properties.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1), cis-
CAS No.	2408962-48-9
Molecular Formula	C7H11F3NO • HCl
Molecular Weight	209.62 (Free base) / 246.08 (Hydrochloride salt)
Synonyms	cis-4-Amino-α,α,α-trifluoro-m-tolylcarbinol hydrochloride; cis-4-Amino-1-(trifluoromethyl)cyclohexanol hydrochloride; (1r,4r)-4-Amino-α,α,α-trifluoro-cyclohexanemethanol hydrochloride; 4-Amino-α,α,α-trifluoro-m-tolylcarbinol hydrochloride (cis-); cis-4-Amino-α,α,α-trifluoro-3-methylcyclohexanemethanol hydrochloride; Fluorinated Cyclohexanolamine Hydrochloride; ATC Hydrochloride (cis- isomer)
EINECS	Contact for details

Quality Control

Every batch of Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1), cis- is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, with specifications tailored for research and process development use. A detailed Certificate of Analysis (COA) including chiral purity by HPLC is supplied with each shipment to guarantee reproducible performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.