Description

2,2-Difluoro-6-Azaspiro[3.4]Octane Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) for use in drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in targeted protein degradation platforms.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring complex, fluorinated spirocyclic structures.

Basic Information

Product Name	2,2-Difluoro-6-Azaspiro[3.4]Octane Hydrochloride
CAS No.	2408959-03-3
Molecular Formula	C7H11ClF2N
Molecular Weight	182.62 g/mol
Synonyms	6-Azaspiro[3.4]octane, 2,2-difluoro-, hydrochloride; 2,2-Difluoro-6-azaspiro[3.4]octane HCl; 2,2-Difluoro-6-azaspiro[3.4]octane hydrochloride; 2408959-03-3; 2,2-Difluoro-6-azaspiro[3.4]octane monohydrochloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-6-Azaspiro[3.4]Octane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.