Description

(R)-5-(4-(2-(3-(Fluoromethyl)Azetidin-1-Yl)Ethoxy)Phenyl)-8-(Trifluoromethyl)-5H-Chromeno[4,3-C]Quinolin-2-Ol is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel therapeutic agents, particularly in oncology and targeted drug discovery. Pharmaceutical R&D teams and fine chemical manufacturers need this precise chiral molecule to develop next-generation small molecule inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic and receptor binding studies due to its specific stereochemistry.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Employed in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs) with complex chromenoquinoline architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	(R)-5-(4-(2-(3-(Fluoromethyl)Azetidin-1-Yl)Ethoxy)Phenyl)-8-(Trifluoromethyl)-5H-Chromeno[4,3-C]Quinolin-2-Ol
CAS No.	2408840-26-4
Molecular Formula	C31H26F4N2O3
Molecular Weight	550.55 g/mol
Synonyms	(R)-8-(Trifluoromethyl)-5-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-5H-chromeno[4,3-c]quinolin-2-ol; UNII-9J8B5QY9VH; 2408840-26-4; (R)-enantiomer of a chromeno[4,3-c]quinoline derivative; Azetidine-containing chromenoquinoline intermediate; Fluoromethyl-azetidine ethoxy phenyl chromenoquinolinol
EINECS	Contact for details

Quality Control

This product is manufactured under strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.