Description

Palladium, [2'-(Amino-κn)[1,1'-Biphenyl]-2-Yl-κc]1-[Bis(1,1-Dimethylethyl)Phosphino-κp]-1'-[Bis(1,1-Dimethylethyl)Phosphino]Ferrocene- is a sophisticated, air-stable palladacycle pre-catalyst designed for high-performance cross-coupling reactions. This compound matters because it combines a bulky, electron-rich ferrocenyl phosphine ligand with a chelating biphenylamine framework, offering exceptional activity and selectivity in challenging transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing complex molecular architectures.

Application

• Buchwald-Hartwig Amination: A highly effective pre-catalyst for C-N bond formation between aryl halides and amines, crucial for synthesizing pharmaceutical intermediates and agrochemicals.
• Suzuki-Miyaura Cross-Coupling: Facilitates the coupling of aryl/vinyl boronic acids with aryl halides for biaryl synthesis, a cornerstone reaction in material science and drug discovery.
• C-S and C-O Bond Formation: Enables the synthesis of aryl thioethers and ethers, valuable motifs in medicinal chemistry and functional materials.
• α-Arylation of Carbonyl Compounds: Used for the selective arylation of ketones and related compounds to create complex, sterically hindered molecules.
• Academic and Industrial Research: Serves as a key tool for methodological development and exploring new catalytic pathways in organic synthesis.
• Scale-up Process Chemistry: Its stability and defined structure make it suitable for transitioning from laboratory-scale discovery to pilot and production-scale manufacturing.

Basic Information

Item	Detail
Product Name	Palladium, [2'-(Amino-κn)[1,1'-Biphenyl]-2-Yl-κc]1-[Bis(1,1-Dimethylethyl)Phosphino-κp]-1'-[Bis(1,1-Dimethylethyl)Phosphino]Ferrocene-
CAS No.	2408294-08-4
Molecular Formula	C41H52FeNOP2PdS
Molecular Weight	823.12 g/mol
Synonyms	Buchwald Palladacycle G4; t-BuBrettPhos Palladacycle; Pd(t-BuBrettPhos)(Biphenyl-2-amine) Methanesulfonate; BrettPhos Palladacycle Pre-catalyst; Pd-PEPPSI BrettPhos analogue; [Pd(AmBippy)(t-BuBrettPhos)]OMs; Palladium(II) [2-(2-Aminobiphenyl)] (di-tert-butylphosphinoferrocenyl) methanesulfonate; Air-stable Pd G4 catalyst.
EINECS	Contact for details

Quality Control

Every batch of our palladium pre-catalyst is synthesized and handled under strict inert atmosphere conditions to prevent oxidation and ensure maximum catalytic activity. We employ advanced analytical techniques including NMR (1H, 31P) and HPLC to verify identity and purity, providing full traceability. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and residual solvent content is supplied with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation and exposure to air. The material is easily oxidized; therefore, handling in a glovebox or using standard Schlenk techniques is recommended for critical applications.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (Pd content)	≥ 12.9% (w/w)
Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.