Description

Bicyclo[1.1.1]pentane-1,3-diamine, N1,N1-dimethyl-, hydrochloride (1:2) is a high-value, structurally constrained diamine derivative, offered as a stable dihydrochloride salt. This compound is a critical building block in modern medicinal chemistry and materials science, prized for its rigid, three-dimensional bicyclo[1.1.1]pentane (BCP) scaffold which serves as a superior bioisostere for linear alkynes or para-substituted benzene rings. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for the development of novel therapeutics, agrochemicals, and advanced polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with improved metabolic stability, solubility, and potency.
• Medicinal Chemistry & Drug Discovery: Used as a sp3-rich bioisostere to replace flat aromatic rings or alkynes, enhancing the drug-like properties of candidate molecules.
• Agrochemical Synthesis: Intermediate in the development of new-generation herbicides, fungicides, and insecticides with novel modes of action.
• Advanced Material Precursor: Serves as a monomer or cross-linker for creating high-performance polymers, resins, and specialty coatings with unique mechanical properties.
• Ligand Synthesis for Catalysis: Used to construct novel, sterically demanding ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Incorporated into bifunctional molecules to confer rigidity and precise spatial orientation.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1,3-diamine, N1,N1-dimethyl-, hydrochloride (1:2)
CAS No.	2387602-38-0
Molecular Formula	C9H20Cl2N2
Molecular Weight	239.18 g/mol
Synonyms	1,3-Bis(dimethylamino)bicyclo[1.1.1]pentane dihydrochloride; N,N,N',N'-Tetramethylbicyclo[1.1.1]pentane-1,3-diamine dihydrochloride; BCP-Diamine (NMe2)2·2HCl; 1,3-Diaminobicyclo[1.1.1]pentane, N,N,N',N'-tetramethyl-, dihydrochloride; [1.1.1]Propellane, 1,3-bis(dimethylamino)-, dihydrochloride; Bicyclo[1.1.1]pentane-1,3-diamine, N,N,N',N'-tetramethyl-, hydrochloride (1:2); Tetramethyl-[1.1.1]propellane-1,3-diamine dihydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1,3-diamine, N1,N1-dimethyl-, hydrochloride (1:2) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding research and scale-up applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.