Description

6-Fluoro-3-Azabicyclo[3.1.0]Hexane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique constrained bicyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to incorporate a fluorinated, rigid amine moiety into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in CNS and psychiatric disorder research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of a fluorinated azabicyclic structure on potency and pharmacokinetics.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development and optimization of commercial-scale API manufacturing routes.
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glues: A valuable component for constructing linkers or warheads in targeted protein degradation platforms.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with enhanced biological activity.
• Chemical Biology & Probe Development: Used to create chemical probes for studying enzyme function and biological pathways.

Basic Information

Product Name	6-Fluoro-3-Azabicyclo[3.1.0]Hexane Hydrochloride
CAS No.	2387598-12-9
Molecular Formula	C6H9FN2·HCl
Molecular Weight	164.61 g/mol (Free base)
Synonyms	6-Fluoro-3-azabicyclo[3.1.0]hexane HCl; 6-Fluoro-3-azabicyclo[3.1.0]hexane hydrochloride; 3-Azabicyclo[3.1.0]hexane, 6-fluoro-, hydrochloride (1:1); 6-Fluoro-3-azabicyclo[3.1.0]hexane monohydrochloride; (1R,5S)-6-Fluoro-3-azabicyclo[3.1.0]hexane hydrochloride; (1S,5R)-6-Fluoro-3-azabicyclo[3.1.0]hexane hydrochloride; 6-Fluoro-3-aza-bicyclo[3.1.0]hexane hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3-Azabicyclo[3.1.0]Hexane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.