Description

THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a specialized heterobifunctional PEG linker featuring a tetrahydropyran (THP) protecting group and a hydroxymethyl-terminated N-methylpyrrolidine moiety. This compound is engineered to provide controlled reactivity and enhanced solubility in aqueous and organic media, making it a critical reagent for advanced bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key spacer and functional component in the construction of next-generation ADCs, connecting cytotoxic payloads to monoclonal antibodies.
• Bioconjugation Reagent: Used for site-specific modification of proteins, peptides, and other biomolecules to improve pharmacokinetics or add functional handles.
• Proteomics Research: Employed in the synthesis of probes and tools for studying protein-protein interactions and cellular pathways.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of complex drug candidates, particularly those requiring PEGylation for enhanced solubility and stability.
• Polymer Chemistry: Functions as a functional initiator or monomer in the synthesis of specialized, biocompatible polymers.
• Diagnostic Agent Development: Utilized in the creation of contrast agents or labeled compounds for imaging applications.

Basic Information

Product Name	THP-PEG4-Pyrrolidine(N-Me)-CH2OH
CAS No.	2378261-81-3
Molecular Formula	C20H39NO7
Molecular Weight	405.53 g/mol
Synonyms	1-((2-(2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)(methyl)pyrrolidin-3-yl)methanol; THP-PEG4-N-Me-Pyrrolidin-3-yl-methanol; 3-(Hydroxymethyl)-1-methyl-1-(2,5,8,11-tetraoxatridecan-13-yl)pyrrolidine THP ether; Tetrahydropyran-protected PEG4 N-methylpyrrolidine methanol; Heterobifunctional PEG linker THP-PEG4-Pyrrolidine; N-Methyl-3-(hydroxymethyl)pyrrolidine PEG4 THP ether
EINECS	Contact for details

Quality Control

Every batch of THP-PEG4-Pyrrolidine(N-Me)-CH2OH is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supplied with a Certificate of Analysis (COA) detailing key specifications such as assay, impurity profile, and moisture content. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.