Description

Spiro[6H-Cyclopenta[B]Pyridine-6,4'-Piperidin]-5-Amine, 5,7-Dihydro-, Hydrochloride (1:2), (5S)- is a high-purity, chiral spirocyclic amine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a sophisticated chemical building block for constructing complex molecular architectures, enabling the exploration of novel therapeutic pathways. It is primarily sought after by pharmaceutical R&D teams and contract research organizations (CROs) engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in catalytic or stoichiometric asymmetric reactions to introduce chirality into complex molecules due to its defined (5S) stereochemistry.
• Chemical Biology Probes: Serves as a starting material for developing tool compounds and molecular probes to study biological pathways and protein function.
• Process Chemistry Development: Used in the scale-up and route scouting phases for developing efficient, scalable synthetic processes for advanced intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	Spiro[6H-Cyclopenta[B]Pyridine-6,4'-Piperidin]-5-Amine, 5,7-Dihydro-, Hydrochloride (1:2), (5S)-
CAS No.	2377355-48-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(5S)-5,7-Dihydrospiro[cyclopenta[b]pyridine-6,4'-piperidin]-5-amine dihydrochloride; (5S)-Spiro[6H-cyclopenta[b]pyridine-6,4'-piperidine]-5-amine dihydrochloride; Spiro[cyclopenta[b]pyridine-6,4'-piperidin]-5-amine, 5,7-dihydro-, hydrochloride (1:2), (5S)-; CAS 2377355-48-9; (5S)-5,7-Dihydro-6H-spiro[cyclopenta[b]pyridine-6,4'-piperidin]-5-amine dihydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[6H-Cyclopenta[B]Pyridine-6,4'-Piperidin]-5-Amine, 5,7-Dihydro-, Hydrochloride (1:2), (5S)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.