Description

Quinoline, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-5,6,7,8-Tetrahydro- is a high-value, chiral heterocyclic compound featuring a fused quinoline-oxazoline structure. This advanced intermediate is critical for the synthesis of complex molecules, offering a versatile scaffold for introducing stereochemical complexity in target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Asymmetric Catalysis Ligand Precursor: The oxazoline moiety makes it a valuable precursor for developing novel chiral ligands used in metal-catalyzed asymmetric reactions.
• Agrochemical Research: Used in the research and development of new, more effective pesticides and herbicides with specific stereochemical requirements.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships (SAR) by modifying the quinoline core to optimize biological activity and pharmacokinetic properties.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the custom synthesis of complex, high-value fine chemicals for various industrial research applications.

Basic Information

Product Name	Quinoline, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-5,6,7,8-Tetrahydro-
CAS No.	2375437-25-3
Molecular Formula	C₁₆H₂₂N₂O
Molecular Weight	258.36 g/mol
Synonyms	(4R)-2-(5,6,7,8-Tetrahydroquinolin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; (R)-2-(5,6,7,8-Tetrahydroquinolin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; 2-[(4R)-4-(tert-Butyl)-4,5-dihydro-1,3-oxazol-2-yl]-5,6,7,8-tetrahydroquinoline; (R)-4-tert-Butyl-2-(5,6,7,8-tetrahydroquinolin-2-yl)-4,5-dihydrooxazole; Chiral Quinoline-Oxazoline Ligand Precursor; Tetrahydroquinoline-oxazoline derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.