Description

4-Bromo-1,1-difluoro-1H-indene is a specialized halogenated and fluorinated indene derivative, serving as a high-value synthetic intermediate. This compound is critical for introducing unique steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in developing new-generation pesticides and herbicides where the difluoromethylene and bromo groups confer enhanced biological activity and metabolic stability.
• Material Science: Serves as a precursor for fluorinated organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis, including those used in cross-coupling reactions.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the behavior of gem-difluoroalkenes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client-specific projects.

Basic Information

Product Name	4-Bromo-1,1-difluoro-1H-indene
CAS No.	2359693-26-6
Molecular Formula	C9H5BrF2
Molecular Weight	231.04 g/mol
Synonyms	4-Bromo-1,1-difluoroindene; 1H-Indene, 4-bromo-1,1-difluoro-; 2359693-26-6; 4-Bromo-1,1-difluoroindene; 1,1-Difluoro-4-bromo-1H-indene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1,1-difluoro-1H-indene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.