Description

n-(Amino-Peg3)-n-Bis(Peg4-Boc) is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and two Boc-protected tetraethylene glycol arms. This compound is engineered to provide controlled spacing, solubility enhancement, and orthogonal reactivity, making it a critical building block in advanced bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing novel therapeutics, drug delivery systems, and functional biomaterials.

Application

• Bioconjugation Linker: Serves as a versatile spacer for conjugating peptides, proteins, antibodies, or small molecule drugs, leveraging the amine group for coupling and the Boc groups for deprotection and further functionalization.
• Drug Delivery System Development: Used to construct sophisticated drug delivery platforms, such as PEGylated liposomes, polymer-drug conjugates, and nanoparticles, to improve pharmacokinetics and target specificity.
• Proteomics Research: Acts as a reagent for cross-linking, labeling, or modifying biomolecules in structural biology and proteomic analysis workflows.
• Hydrogel and Biomaterial Synthesis: Functions as a cross-linking agent or monomer for creating biocompatible hydrogels and scaffolds with tailored degradation and mechanical properties for tissue engineering.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic assays and imaging probes where water solubility and controlled attachment of recognition elements are required.
• Click Chemistry and Polymer Chemistry: Provides a functional handle for copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating the synthesis of complex polymer architectures.

Basic Information

Product Name	n-(Amino-Peg3)-n-Bis(Peg4-Boc)
CAS No.	2353409-57-9
Molecular Formula	C37H74N2O17
Molecular Weight	819.0 g/mol (approx.)
Synonyms	1-Amino-3,6,9,12,15,18,21,24,27,30,33,34-dodecaoxa-2-azapentatriacontan-35-oic acid, 35-[(1,1-dimethylethoxy)carbonyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxa-34-azapentatriacontan-1-aminium; 2,5,8,11,14,17,20,23,26,29,32-Undecaoxa-34-azapentatriacontan-1-aminium, 35-[(1,1-dimethylethoxy)carbonyl]-1-amino-3,6,9,12,15,18,21,24,27,30,33,34-dodecaoxa-2-azapentatriacontan-35-oate; Amino-PEG3-Bis(PEG4-Boc); Boc-PEG4-NH-PEG3-N(Boc-PEG4); Heterobifunctional PEG Amine Bis(Boc-PEG4); N1-(2-Aminoethyl)-N1,N11-bis[2-[2-[2-[2-(1,1-dimethylethoxy)carbonylamino]ethoxy]ethoxy]ethoxy]ethyl]-3,6,9,12-tetraoxapentadecanediamide
EINECS	Contact for details

Quality Control

Our n-(Amino-Peg3)-n-Bis(Peg4-Boc) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.