Description

(R)-3-(tert-Butyl)-4-(3,5-Diisopropyl-2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a sophisticated chiral organophosphorus compound that serves as a high-value building block and ligand in advanced synthetic chemistry. Its unique sterically hindered and electron-rich structure makes it an essential component for developing asymmetric catalytic systems, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. This product is primarily targeted at R&D scientists and process chemists in pharmaceutical development, agrochemical research, and specialty materials synthesis who require precise stereochemical control.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or precursor for transition metal catalysts in enantioselective hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Acts as a monomer or additive in the development of chiral polymers and advanced functional materials with specific optical properties.
• Academic & Industrial Research: A valuable tool for method development in organic synthesis and catalysis within university laboratories and corporate R&D centers.
• Process Chemistry Optimization: Investigated for scaling up enantioselective manufacturing processes to improve yield, selectivity, and cost-efficiency.

Basic Information

Item	Details
Product Name	(R)-3-(tert-Butyl)-4-(3,5-Diisopropyl-2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	2351219-90-2
Molecular Formula	C26H35O3P
Molecular Weight	426.53 g/mol
Synonyms	(R)-DTB-DiP-DM-BOP; (R)-3-tert-Butyl-4-(3,5-diisopropyl-2,6-dimethoxyphenyl)-2,3-dihydro-1,3-benzoxaphosphole; (R)-Benzoxaphosphole Ligand; Chiral Dihydrobenzooxaphosphole; (R)-Tert-Butyl Diisopropyl Dimethoxy Benzoxaphosphole; Asymmetric Phosphole Ligand; (R)-Configuration Organophosphorus Heterocycle
EINECS	Contact for details

Quality Control

Every batch of (R)-3-(tert-Butyl)-4-(3,5-Diisopropyl-2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and enantiomeric excess. Our standard R&D grade material is characterized by NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) with full analytical data, including chiral purity confirmation, are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.