Description

(R)-3-(tert-Butyl)-4-(2,6-Dimethoxy-3,5-Dimethylphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a high-value, chiral organophosphorus compound characterized by its unique benzo[d][1,3]oxaphosphole core. This compound is a critical advanced pharmaceutical intermediate (API) and a sophisticated ligand precursor for asymmetric catalysis. It is essential for research and manufacturing organizations developing novel therapeutics and catalytic processes that require precise stereochemical control. This product is supplied with a CAS number of 2351219-88-8.

Application

• Asymmetric Catalysis: Serves as a key precursor for the synthesis of novel chiral phosphine-phosphite (P-OP) or related hybrid ligands used in transition metal-catalyzed reactions like hydrogenation and cross-coupling.
• Pharmaceutical Intermediates: A crucial building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), particularly for targets requiring complex, stereodefined molecular architectures.
• Agrochemical Research: Used in the development of new chiral pesticides and herbicides where the specific stereochemistry can influence biological activity and environmental profile.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique optical or electronic properties.
• Academic & Industrial R&D: A valuable tool for chemists exploring new methodologies in organophosphorus chemistry and stereoselective synthesis.

Basic Information

Product Name	(R)-3-(tert-Butyl)-4-(2,6-Dimethoxy-3,5-Dimethylphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	2351219-88-8
Molecular Formula	C22H29O3P
Molecular Weight	372.44 g/mol
Synonyms	(R)-3-tert-Butyl-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydro-1,3-benzoxaphosphole; (R)-DTBM-BOAP; (R)-DTBM-Benzoxaphosphole; (R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole ligand precursor
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral compound adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.