Description

Benzenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)- is a specialized, non-natural amino acid derivative featuring a protected α-amino group via the 9-fluorenylmethoxycarbonyl (Fmoc) group and an iodine substituent on the aromatic ring. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise incorporation of iodinated phenylalanine analogs into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing peptide-based therapeutics, diagnostic probes, and tools for chemical biology where site-specific modification or radiolabeling is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected iodinated amino acid, it serves as a key monomer for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used to create peptide drug candidates with unique properties, such as those intended for targeted radiotherapy or as molecular imaging agents.
• Chemical Biology & Bioconjugation: The iodine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Sonogashira, Suzuki) to attach fluorophores, biotin, or other moieties.
• Proteomics & Peptide Library Construction: Enables the generation of diverse peptide libraries containing halogenated residues for screening against biological targets.
• Material Science: Can be incorporated into peptide-based biomaterials or surface coatings where halogenated aromatic groups influence self-assembly or material properties.

Basic Information

Product Name	Benzenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)-
CAS No.	2349795-42-0
Molecular Formula	C25H22INO4
Molecular Weight	527.35 g/mol
Synonyms	Fmoc-4-iodo-L-homophenylalanine; Fmoc-L-4-iodohomophenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-iodophenyl)butanoic acid; Fmoc-4-Iodo-homoPhe-OH; N-α-Fmoc-4-iodo-L-homophenylalanine; Fmoc-4-I-homoPhe-OH; 4-Iodo-L-homophenylalanine, N-Fmoc derivative; Nα-Fmoc-4-iodo-L-homophenylalanine
EINECS	Contact for details

Quality Control

Our Benzenebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including GMP-grade standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and light-sensitive nature, this material should be stored in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and moisture uptake. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.