Description

n-Fmoc-D-Homophe(4-No2)-Oh is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide structure and function, particularly in the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on peptide-based drug discovery and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of modified phenylalanine analogs into peptide chains.
• Peptidomimetic Drug Development: Used to create peptide-like molecules with enhanced stability, bioavailability, and target specificity for therapeutic applications.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms by introducing specific structural and electronic modifications.
• Pharmaceutical Intermediate: Serves as a high-value intermediate in the synthesis of complex Active Pharmaceutical Ingredients (APIs) for clinical trials.
• Protease Substrate Analog Synthesis: Facilitates the creation of specific substrates or inhibitors for enzyme activity studies.

Basic Information

Product Name	n-Fmoc-D-Homophe(4-No2)-Oh
CAS No.	2349606-35-3
Molecular Formula	C26H24N2O6
Molecular Weight	460.48 g/mol
Synonyms	Fmoc-D-homo-Phe(4-NO2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homo-4-nitrophenylalanine; Fmoc-D-4-nitrohomo-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-nitrophenyl)butanoic acid; D-4-NitrohomoPhe(Fmoc)-OH; Fmoc-D-Hph(4-NO2)-OH; Fmoc-D-Homo(4-NO2)Phe-OH; Fmoc-D-β-homo-4-nitrophenylalanine
EINECS	Contact for details

Quality Control

Our production of n-Fmoc-D-Homophe(4-No2)-Oh adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We maintain traceability and compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.