Description

Benzenehexanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Fluoro-, (αr)- is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a fluorine substituent. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and peptidomimetics for research and development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories focused on drug discovery, proteomics, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a fundamental monomer for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Research & Development: Used to incorporate fluorinated, non-natural amino acids into peptide-based drug candidates to enhance metabolic stability, bioavailability, and binding affinity.
• Peptidomimetic Design: A key precursor for creating peptide analogs and mimetics that mimic natural protein structures for therapeutic applications.
• Chemical Biology & Proteomics: Employed in the synthesis of peptide probes, substrates, and inhibitors for studying enzyme function and protein-protein interactions.
• Bioconjugation: The reactive carboxylic acid group allows for further functionalization and conjugation to other molecules, carriers, or surfaces.
• Material Science: Potential use in the synthesis of specialized peptide-polymer hybrids or biomaterials with tailored properties.

Basic Information

Product Name	Benzenehexanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Fluoro-, (αr)-
CAS No.	2349416-79-9
Molecular Formula	C27H24FNO5
Molecular Weight	461.48 g/mol
Synonyms	Fmoc-4-fluoro-D-homophenylalanine; Fmoc-4-F-D-homoPhe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-fluorophenyl)butanoic acid; N-α-Fmoc-4-fluoro-D-homophenylalanine; Fmoc-D-4-F-homoPhe; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-D-homophenylalanine; Fmoc-4-F-D-hPhe-OH
EINECS	Contact for details

Quality Control

Our Benzenehexanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Fluoro-, (αr)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.