Description

(S)-3-(2-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a unique ethynylphenyl side chain and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of rigid, aromatic structures and facilitating further functionalization via click chemistry. It is primarily utilized by pharmaceutical R&D and biotechnology companies for the development of novel therapeutic agents, including protease inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and metabolic disease research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a constrained, aromatic amino acid residue with an alkyne handle for post-synthetic modification.
• Chemical Biology Probes: Serves as a building block for creating activity-based probes and bioconjugation linkers, leveraging the ethynyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptidomimetic Design: Essential for developing peptide mimics with enhanced metabolic stability and binding affinity by introducing conformational rigidity.
• Library Synthesis: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for drug discovery.
• Material Science: Potential use in creating functionalized surfaces and polymers where precise spatial arrangement of aromatic and reactive groups is required.

Basic Information

Product Name	(S)-3-(2-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid
CAS No.	2349416-34-6
Molecular Formula	C26H21NO4
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-(S)-2-amino-3-(2-ethynylphenyl)propanoic acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-ethynylphenyl)propanoic acid; Fmoc-Aep(2-Ethynyl)-OH; Fmoc-3-(2-Ethynylphenyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-ethynylphenyl)-L-alanine; Non-natural Fmoc-amino acid; Fmoc-protected ethynylphenylalanine derivative
EINECS	Contact for details

Quality Control

Our (S)-3-(2-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.