Description

Endo-2-Azabicyclo[2.2.1]Heptan-6-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 2322934-56-3. This compound is a crucial chiral building block valued for its rigid bicyclic structure, which is essential for imparting specific three-dimensional conformation and biological activity in final drug molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas such as neurology and metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs.
• Medicinal Chemistry Research: Used as a scaffold in drug discovery programs to explore structure-activity relationships (SAR) and develop new chemical entities.
• Asymmetric Synthesis: Employed as a precursor or catalyst ligand in stereoselective synthesis due to its defined endo configuration.
• Preclinical Development: Supplied in development quantities for formulation studies, pharmacokinetic profiling, and toxicology assessments.
• Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Endo-2-Azabicyclo[2.2.1]Heptan-6-Ol Hydrochloride
CAS No.	2322934-56-3
Molecular Formula	C6H12ClNO
Molecular Weight	149.62 g/mol
Synonyms	6-Hydroxy-2-azabicyclo[2.2.1]heptane hydrochloride; endo-6-Hydroxy-2-azanorbornane hydrochloride; 2-Azabicyclo[2.2.1]heptan-6-ol, endo-, hydrochloride; (1R,2S,4S,5R)-2-Azabicyclo[2.2.1]heptan-6-ol hydrochloride; endo-6-Hydroxy-2-azabicyclo[2.2.1]heptane HCl
EINECS	Contact for details

Quality Control

Our Endo-2-Azabicyclo[2.2.1]Heptan-6-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (endo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.