Description

3-Ethoxybicyclo[1.1.1]pentan-1-amine hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique strained bicyclic scaffold. This compound is valued for its role in medicinal chemistry, particularly in the development of novel bioactive molecules and drug candidates targeting the central nervous system and other therapeutic areas. It is essential for research and development chemists in pharmaceutical, biotechnology, and fine chemical synthesis sectors seeking to incorporate the rigid, three-dimensional [1.1.1]propellane structure into new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in fragment-based drug discovery.
• Medicinal Chemistry Research: Used to explore structure-activity relationships (SAR) by introducing a rigid, sp3-rich bioisostere into lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of new active ingredients with unique modes of action.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and the properties of strained ring systems.

Basic Information

Product Name	3-Ethoxybicyclo[1.1.1]pentan-1-amine Hydrochloride
CAS No.	2306272-15-9
Molecular Formula	C7H14ClNO
Molecular Weight	163.64 g/mol
Synonyms	1-Amino-3-ethoxybicyclo[1.1.1]pentane hydrochloride; 3-Ethoxybicyclo[1.1.1]pentan-1-amine HCl; 3-Ethoxy-[1.1.1]propellan-1-amine hydrochloride; 1-Amino-3-ethoxy[1.1.1]propellane hydrochloride; Bicyclo[1.1.1]pentan-1-amine, 3-ethoxy-, hydrochloride; Ethoxy[1.1.1]propellane-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Ethoxybicyclo[1.1.1]pentan-1-amine hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.