Description

3-(Trifluoromethoxymethyl)Azetidine Hydrochloride is a high-value, nitrogen-containing heterocyclic building block with a trifluoromethoxy functional group. This compound is critical for medicinal chemistry and agrochemical research, enabling the introduction of a metabolically stable, lipophilic moiety that can significantly alter the pharmacokinetic properties of lead molecules. It is primarily sought after by R&D and process development teams in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and tool compounds to study biological pathways and protein function.
• Material Science Research: Potential monomer or additive for developing specialty polymers with unique surface properties or fluorine-containing functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	3-(Trifluoromethoxymethyl)Azetidine Hydrochloride
CAS No.	2306268-29-9
Molecular Formula	C6H9ClF3NO
Molecular Weight	203.59 g/mol
Synonyms	3-[(Trifluoromethoxy)methyl]azetidine hydrochloride; Azetidine, 3-[(trifluoromethoxy)methyl]-, hydrochloride (1:1); 3-(Trifluoromethoxymethyl)azetidine HCl; 1-Azabicyclo[1.1.0]butane, 3-[(trifluoromethoxy)methyl]-, hydrochloride; (Azetidin-3-ylmethoxy)(trifluoro)methane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethoxymethyl)Azetidine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.