Description

(S)-6-(((tert-Butyldimethylsilyl)Oxy)Methyl)-5-Azaspiro[2.4]Heptane is a high-value, chiral spirocyclic building block used in advanced pharmaceutical synthesis. Its unique constrained spiro[2.4]heptane scaffold and protected functional groups make it a critical intermediate for developing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. This compound is essential for medicinal chemists and process development scientists seeking to introduce complex three-dimensionality and specific stereochemistry into lead molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore novel chemical space due to its spirocyclic architecture.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of complex target molecules.
• Asymmetric Synthesis: Utilized in the construction of enantiomerically pure compounds where the (S)-configuration is required for biological activity.
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glue Development: Potential incorporation into bifunctional linker systems due to its rigid, three-dimensional structure.
• Chemical Biology Probes: Can be used to create tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-6-(((tert-Butyldimethylsilyl)Oxy)Methyl)-5-Azaspiro[2.4]Heptane
CAS No.	2305842-41-3
Molecular Formula	C14H29NOSi
Molecular Weight	255.47 g/mol
Synonyms	(S)-6-(((tert-Butyldimethylsilyl)oxy)methyl)-5-azaspiro[2.4]heptane; (S)-5-Azaspiro[2.4]heptane-6-methanol, 1-(1,1-dimethylethyl)-1,1-dimethylsilyl ether; (S)-6-((tert-Butyldimethylsilyloxy)methyl)-5-azaspiro[2.4]heptane; TBS-protected (S)-5-azaspiro[2.4]heptane-6-methanol; (S)-6-(TBDMSO-methyl)-5-azaspiro[2.4]heptane; (S)-N-Boc-6-((tert-butyldimethylsilyloxy)methyl)-5-azaspiro[2.4]heptane (common precursor); Chiral spirocyclic TBS ether
EINECS	Contact for details

Quality Control

Our (S)-6-(((tert-Butyldimethylsilyl)Oxy)Methyl)-5-Azaspiro[2.4]Heptane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and process development. A detailed Certificate of Analysis (COA) providing HPLC/GC purity, chiral HPLC assay, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the material in a freezer at -20°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.